Diagnostics of primary aldosteronism: is obligatory use of confirmatory tests justified?

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15 صفحه اول

Confirmatory testing in primary aldosteronism: extensive medication switching is not needed in all patients

OBJECTIVE Confirmatory testing of suspected primary aldosteronism (PA) requires an extensive medication switch that can be difficult for patients with severe complicated hypertension and/or refractory hypokalemia. For this reason, we investigated the effect of chronic antihypertensive medication on confirmatory testing results. To allow the results to be interpreted, the reproducibility of conf...

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Primary aldosteronism: diagnostic accuracy of the losartan and captopril tests.

BACKGROUND To assess whether angiotensin-II receptor blockers (ARBs) offer any additional advantage in confirming the diagnosis of primary aldosteronism (PA) and their use in the differentiation of PA subtypes. METHODS A prospective, cohort, head-to-head study was conducted between July 2003 and July 2006. A total of 135 patients received captopril and losartan tests to confirm the diagnosis ...

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Establishment of reference values for endocrine tests. III: Primary aldosteronism.

BACKGROUND In our laboratory well-defined reference values for the screening test and confirmation test used in the diagnosis of primary aldosteronism were lacking. In this study we established the reference-values of the plasma aldosterone concentration (PA), plasma renin activity (PRA) and PA/PRA ratio after a two-hour upright period, and of the urinary aldosterone excretion after oral sodium...

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Eplerenone use in primary aldosteronism during pregnancy

Primary aldosteronism (PA) in pregnancy is rare. Due to pharmacological limitations and risks associated with surgical intervention during pregnancy, clinical decision making in this area is difficult. We report the short-term use of eplerenone in the management of hypertension and hypokalemia due to PA in pregnancy.

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ژورنال

عنوان ژورنال: Journal of the Renin-Angiotensin-Aldosterone System

سال: 2012

ISSN: 1470-3203,1752-8976

DOI: 10.1177/1470320312438791